Collagen is the most polymer in the ECM of the skin. Therefore one of the best options for prepering scaffold in skin TE is the use of collagen, but one of its biggest constraint is shrinkage & contraction. So what is the solution to prevent or reduce collagen contractions?
scaffolds made of type I collagen exhibit contractility, which occurs as part of
osteogenesis in native tissues. Recently, it has been demonstrated that increased contraction of type I collagen enhances repair and regeneration of bone with specific application in the treatment of osteochondral lesions and osteoarthritis . Conversely, the resistance to contraction exhibited by type II collagen offers a potential solution to the problem of maintaining shape of engineered tissues. In particular, use of a type II collagen scaffold prevented shrinkage and shape change of tissue-engineered ear cartilage implants.
You can read below article:
Review
Heterogeneity of Scaffold Biomaterials in Tissue Engineering
Lauren Edgar, Kyle McNamara, Theresa Wong, Riccardo Tamburrini, Ravi Katari and
Giuseppe Orlando *
Please also see this previous Q/A on RG which might be helpful
https://www.researchgate.net/post/What_is_the_proper_collagen_gel_preparation_method2
TETRACYCLINE-BASED METALLOPROTEINASE INHIBITORS MAY REDUCE CONTRACTION OF COLLAGEN.
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