The relationship between gene expression and disease was widely known, however, is the gene ratio (Gene A expression value/Gene B expression value) might cause any diseases or phenotypes in any organism?
You are going to have to give a LOT more details if you want helpful responses. What organism (human, mouse, strawberries, etc.)? What disease? Are you talking about gene expression or gene duplication or mtDNA depletion or another phenomenon?
To verify outcome of gene ratios, it is better to do proteomics analysis or at least Western to verify their protein expression. However, you can use Ingenuity or String tools to know the relationship among genes.
Yes. There are diseases and phenotypes that are due to differences in gene expression. WHICH disease or phenotype or organism(s) are you studying?
If this is serious research question, then you need to start by reading the literature. If you are just hoping for someone to answer your homework question for you, then you should go back and read your notes.
Gene expression data often come with a regular gene database. I would recommend exploring your species and tissue to see you could come up with a testable hypothesis.
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