i have been working on the anti-inflammatory effect of Spirulina (Arthrospira platensis) on the S. mansoni induced granulomatous response. but one i have completed the experiment i have found a controversial result among treatment dose and route. i have been trying to explain it in terms of cytokines that intermediate the delayed type inflamatory response, but i have found that there is no clear understanding of cytokines and chemokines involved and their actual effect during acute and chronic stages of the infection. so is there any one that can help me by explaining this facts. thanks
It is not any particular cytokine affecting pathogenesis but profile of cytokines and balance between different pro and anti inflammatory cytokine determines the pathogenesis and it varies fr4om disease to disease with the type of infecting agent
thanks for your reply, but what i was trying to ask was that exact profile is responsible? because there is a conflicting explanations based on Th1 mediated cytokines and that of Th2.
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