Dear Dr Franz Schelling

Multiple sclerosis (MS) is characterized by the presence of lesions in the central nervous system (CNS) that are disseminated in both space and time. This means that the disease affects different areas of the CNS and that these lesions occur at different points in time. This concept is essential for diagnosing and understanding the pathophysiology of MS. Here's what justifies this characterization.

Dissemination in Space:MS typically involves multiple lesions in different parts of the central nervous system, including the brain and spinal cord. These lesions can be observed in various regions of the CNS, and their distribution can be widespread. The presence of lesions in different areas of the CNS is a key diagnostic criterion for MS. The lesions must be separated anatomically to meet the criteria for dissemination in space. Dissemination in Time:MS is a chronic disease characterized by the development of new lesions over time. Patients often experience relapses or exacerbations, during which new symptoms or worsening of existing symptoms occur. These relapses are associated with the formation of new lesions. The progression of the disease can vary from person to person, and new lesions may appear at different intervals. The presence of new lesions occurring at different times is another diagnostic criterion for MS, indicating dissemination in time.

To diagnose MS, healthcare professionals often rely on clinical evaluation, imaging studies (such as MRI), and other diagnostic criteria. The "McDonald criteria" is a widely used set of guidelines for diagnosing MS, which takes into account both spatial and temporal dissemination of lesions.

The characteristic dissemination of lesions in space and time in MS reflects the underlying autoimmune nature of the disease. In MS, the immune system mistakenly targets and damages the myelin sheath that surrounds nerve fibers in the CNS. This immune-mediated attack can occur at various sites within the CNS and may occur episodically, leading to the observed patterns of lesion dissemination.

Understanding the dissemination of lesions in space and time is crucial for diagnosing MS, tracking disease progression, and guiding treatment decisions. Early diagnosis and intervention can help manage the condition and improve the quality of life for individuals living with MS.

Kind regards

AB Bayazid

Article Archetypal Analysis of Visual Fields in Optic Neuritis Revea...

Article Validating archetypes for the Multiple Sclerosis Functional Composite

My sincere apologies, AB Bayazid:

Do you believe repeating well-propagated statements, especially such a long series of affirmations, is offering some proof for, or that it amounts to some documentation in support of them?

When will clinical neurology get tired of continually asserting clinical convened assumptions about multiple sclerosis?

Is there no necessity to explain how the ostensibly pragmatic thinking patterns have come about?

What about the unmistakable pictorial MS documents shown at www.ms-info.net? What about weighing such findings against the above-given claims?

Searching for a Direct Route to Multiple Sclerosis Treatment

Researchers created a new high-throughput tool to hunt for therapies that remyelinate the nervous system...

"In MS, a patient’s immune system mistakenly attacks the myelin sheath. Inflammation damages the neurons left vulnerable by demyelination, and causes a range of symptoms, including vision loss, muscle weakness and dysfunction, and sensory changes. Current MS therapies target the immune system to slow disease progression, but scientists seek a more direct therapeutic approach. “Just by stopping the immune system, you can’t recover the myelin that’s degraded,” explained Xitiz Chamling, a neuroscientist at Johns Hopkins University. “There is a huge interest in this field to re-establish myelin, which is called remyelination.” This interest stems from the potential to cure or reverse the disease with treatments that promote myelination by oligodendrocytes...""

https://www.cell.com/iscience/fulltext/S2589-0042(23)00233-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS258900422300233X%3Fshowall%3Dtrue

https://www.the-scientist.com/news/searching-for-a-direct-route-to-multiple-sclerosis-treatment-71218?utm_campaign=TS_DAILY_NEWSLETTER_2023&utm_source=hs_email&utm_medium=email&utm_content=285134291&_hsenc=p2ANqtz--s4H6wLJKeudSsj5ERvguyTIXAq8cVxEbHz_yMLLqtoxeHRqundTJk1hFdcTaTQdPOQzKSa5bDCi6zT5iR_fQdEBh0xw

Ljubomir Jacić, are you sure the hunt follows the right tracks?

Who and what proved the immune system's attack on myelin sheaths? Who or what reconciled this claim with what MS shows in the myelin-free retina and choroid membrane? Or with the Dawson's finger's orientation and thrust?