The acidic catalyst can be usful to preparation sulfonoamide.

Good luck

Hello Melford,

thank you for sharing this interesting chemical question with the RG community. There is a vast body of literature regarding the synthesis of sulfonamides available, and there are different synthetic routes and various catalysts known. Thus the choice of the "best" catalyst depends on the indiciofual synthetic route (e.g. starting with sulfonyl chlorides). In other words, there is no general answer to your question. I suggest that you use RG directly as a valuable source of information. For example, search the "Publications" section for terms like "catalyst for sulfonamide synthesis". This will provide you with many relevant literature references which have been posted by RG members, some of them even as public full texts:

https://www.researchgate.net/search.Search.html?type=publication&query=%20catalyst%20for%20sulfonamide%20synthesis

Good luck with your work and best wishes!

Sulfonamides are normally prepared by coupling of sulfonyl chlorides and amines. This reaction is catalyzed by a base, usually by a tertiary amine (Py, Et3N, Hunig's base, etc. - depends on the amino component).

The other function of the tertiary amine in this reaction is scavenging of the released acid, which means that you need at least one equivalent of it. If the amine used for sulfonamide preparation is inexpensive, and if it is easily removable, it can be used in excess (~x2); in this case the additional base is not required.

Hope this helps.

The buffer medium can be useful to neutralize the liberation of HCl during point of reaction time that its role is activation of the carbonyl group and allowing it to react with the nucleophilic amine. Beacause the excess of HCl will protonate all the amine (nucleophile) , so the best is using HCL scavenger, usually it is a tertiary amine, pyridine or TEA ( non - nucleophilic bases)

I hope this provides a clear vision for your work.

And you can take view on this paper

doi:10.3390/cryst9010035

Along with pyridine and trialkyl amine in some cases di alkyyl amine are also used.i.e by preparing it from sulfonic acid precursor

Here is the reaction 1.1.2

Dear researchers,

I have used nickel catalyst to synthesize sulfonamide, the reaction was not bad, however, I want to know if there is a better catalyst to use