- As we known, the naive B cell activation depend on T cell. The antigen alone cannot trigger B cell differentiation. However, whether the memory B cell could be activated by antigen without Th cell signaling?
Actually, with certain antigens - ones that have a repetitive structure - primary B cells CAN be activated without T cell help. These antigens are known as T-independent antigens.
But memory B cells are absolutely dependent on T cell help. I spent several years as a post-doc working with Norman Klinman at Scripps on this precise topic. Look for a review by Phyllis-Jean Linton and Norman Klinman; she published that back in the late 80's early '90s. I do not remember the name of the journal.
Hello Jingwei Huang
I agree with Dr. Gary Lee Gilmore . Memory B-cells need T-cell activation unless and until the antigen is composed of polyacrylamide (sugar) or free DNA (derived from a virus).
T-cells can only present protein (peptide) antigens to memory B-cells. Some types of antigens need T-cells as a go-between to activate memory B-cells. These types of antigens are termed as T-cell-dependent antigens. Some types of antigen can be identified and fought by B-cells without T-cell activation. These are called T-cell-independent antigens.
Best.
Yes memory B cell need T cell help to be activated, because B cell need a co-stimulatory signals.
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