Short answer - yes. Easiest way to increase S/N is possibly to increase temperature (thus increasing tumbling time). Look up dependence of T1 & T2 with temperature.

Thank you for the answers Dr Robert and Clemens .Currently I am adding 30 mg of Maleic acid in 1g D2O to use it as a an external reference standard in Quantitative NMR. As I need to develop a more rugged method I do not have the freedom to increase the higher  temperature.First  I may try with a small volume tube and I am not having the freedom to decrease the concentration of the ref standard which add up error from weighing the sample at low concentration.Do you have any recommendation on NMR tubes. Currently we are using 5 mm Wilmad-535 PP.Does the 3mm NMR tube will be sufficient or any special grade is required. Can you refer any article where I can get an idea on Sample resistance.

I think Dr Anklin will be more help than I could be. If you limit the viscosity & temperature ... I think you are thown on the the limited cross of instrumental improvements (which Dr Anklin can explain ..after all Bruker scientists are very good at this). However, given the limitationsof nmr, have you really thought about what you wish to achieve? Can you think of a better experiment?  One of my mentors..long time ago .. said that to be limited to one technique is 'tunnel vision'. Think outside the box.

Thank you for guidance and motivation. Quantification with Internal standard may work but  we are now interested  to check the feasibility of QNMR with  External referencing technique using maleic acid as reference using D2O as solvent. May be I need to  look on another reference standard other than maleic acid in D2O solvent

Thank you for sharing the article.We  are using Bruker instrument with Topspin.  I am novice to  electronic referencing . We will try the ERETIC method.

Milesh