Where is the location of von Hippel-Lindau protein in the cell?

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Goodwin G. Jinesh

It should be in both cytoplasm and nucleus.

http://www.ncbi.nlm.nih.gov/pubmed/12937142

Chi sheng Wu

Thank you Goodwin, I will read the article.

Shrikant Pradhan

VHL is mainly present in the cytoplasm as it is responsible for marking various proteins for proteasomal degradation. However, some isoforms are also preset in the nucleus.

It can also go to endosome assumed based on my paper.

https://www.researchgate.net/publication/317184577_RalBP1_and_p19-VHL_play_an_oncogenic_role_and_p30-VHL_plays_a_tumor_suppressor_role_during_the_blebbishield_emergency_program

Article RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays...