BDNF has been discovered in maxillary glands of rats, homologous to human submandibular glands.
Data 2011 - Minelli EurArchPsychiatryClinNeurosc i2011 BDNF
From macrophages for example. Macrophages can express neurotrophins and their receptors!
Many systemic sources may synthesize and release the neurotrophin
in blood as epithelial cells, vascular endothelial cells,muscle cells, activate macrophages and lymphocytes. Platelets store the major part of serum BDNF: difference between plasma and serum BDNF content is 1:20.
I appreciate the quantitaive information you give. NGF was discovered dalla Rita in the maxillary and submandibulary gland of the rat, which is the submandibular gland in us. Tsukinoki found stress-related increases BDNF etc.in the SMG ( http://www.ncbi.nlm.nih.gov/pubmed/23209335 ) and Mathison reveiws the many effects of SMG substances ( http://www.benthamscience.com/open/toinfj/articles/V002/9TOINFJ.pdf ). BDNF does not cross the BB easily. SO how much is from the SMG, and how much from the platelets?
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