Anybody knows that when the adjuvant chemotherapy (ACT) of colon cancer was recommended for the first time in the guidelines?
The first evidence of the survival benefit of 5FU-based ACT over surgery alone in stage II-III colon cancer patients was reported from NSABP C-01 trial in 1988, which was afterward confirmed by later pooled analyses. Following these pioneering studies, 5FU deemed to be the standard control arm in newer CRTs which were consequently unable to investigate the effectiveness of the innovative surgery alone treatments (e.g. complete mesocolic excision) of colon cancer. Surprisingly, The disease-free and overall survival benefit of ACT reported in NSABP C-01 trial disappeared after ten years in an updated analysis, making a glass ceiling for the real effectiveness of ACT in clinical practice. I am working on this story and would like to know how the ACT came to the guidelines as a standard treatment of colon cancer.
Dear Dr Babaie
This Article might be useful
Adjuvant Treatment of Colorectal Cancer
Alfredo Carrato,
Kind regards
NA
Dear Dr. Amini
Thanks a lot for your message and suggestion,
Best regards, Masoud
I think NSABP C-01 was the positive study showing some benefit from adjuvant chemotherapy:
https://www.ncbi.nlm.nih.gov/pubmed?term=3276901