The initial age of therapy/prophylaxis with cimetidine made possible a dramatic reduction of the issue. Nowadays, starting from two or three years although we have last generation antiulcer drugs and sophisticated diagnostic technique, we are assisting a new era of acute gastric perforations. It seems a jump in the past. The problem is observed not only in ethnic minorities where is more difficult to reach a good quality of life, but even in resident people with a good wellness of life. Whats going on? Self prescription medications? Changing in lifestyles? Escape from official medicine?
I'm very interested in your eventually observations and opinions.
Very interesting observations and questions. Obviously, with the introduction of modern antiulcer therapy incidents of acute gastric perforation have become much less common. In some countries this pathology is generally treated as a medical casuistry. In Ukraine within 2-3 years, we are also seeing increased gastric perforations. In my opinion, in my country this phenomenon is easily explained by the economic crisis - the impoverishment of the population, worse access to medicine, powerful social stress … Spanish surgeons have also concluded, that increase of incidence of gastric perforations in 2012 can be related to therapeutic interruption for economical causes (PEPTIC ULCER PERFORATION: A 3-YEAR EXPERIENCE OF A GENERAL SURGERY DEPARTMENT Mora H., Muralha N., Gonçalves F., Gouveia A., Barbosa J., Costa-Maia J. 2nd WJES & WSES Meeting, Bergamo, July 7-9, 2013/Abstract book, p. 43). Obviously, a reasonable explanation of this phenomenon requires proper investigation.
Thank you for the question!
IMHO, there are several possible explanations:
1) lack of proper theory of the peptic ulcer disease pathogenesis (I can explain lower, if you please);
2) a certain cyclicity of the peptic ulcer disease prevalence from a decade to another;
3) lack of the proper statistical data for this prevalence, the ulcer chronicisity, recurrences, complications, and so on.
4) there might exist certain conceptual frames for authors in the peer-reviewed editions as to accept or not accept their viewpoints on various discussable aspects of the peptic ulcer disease.
May H. pylori infection or non-steroidal anti-inflammatory drug auto-medication have played a role in this phenomenon?
we in a major corporate setup,do not see that many DU perforations.Incidence of peptic ulcer disease was very common in south India attributed once to High spicy food,but after the advent of H2receptor antagonists and ppis,it was almost disappeared except few perforations in public hospitals.Certainly now there seems to be a reappearance due to above mentioned reasons by Dr Ireradi and also due to modern life style changes adopted in this part of the world as well.
- Badges
- Science topic
- Similar topics
- Physical Sciences
- Physical Phenomena
- Luminescence
- Fluorescence