For small molecule drug discovery, we use PAMPA assay to classify compounds into three categeories, high, medium to high and low permeability. My question js that what`s the value of high, medium to high and low permeability? where dose these values come from? any paper mentioned these?
Here is some useful information on the PAMPA assay:
https://www.cyprotex.com/admepk/in-vitro-permeability/pampa
"The compounds can be categorized into low and high permeability. Generally, compounds which have a Papp < 10 x 10-6cm/s are classified as low permeability and compounds with a Papp > 10 x 10-6cm/s are classified as high permeability."
Dear Jack Hong
These articles might be useful, have a look:
1. https://web.ornl.gov/sci/buildings/conf-archive/2007%20B10%20papers/023_Becker.pdf
2. https://www.merckmillipore.com/INTERSHOP/static/WFS/Merck-Site/-/Merck/en_US/Freestyle/newsletter/ps/pharmail/2014/Buffer_Sizing_article_MM.pdf
3. https://www.globalgilson.com/blog/soil-permeability-test
4. https://journals.sagepub.com/doi/pdf/10.1177/0143624418822199
Kind Regards
Qamar Ul Islam
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