What would be the specific dose for my drug in for animals use?

More Sushil Kumar Middha's questions See All

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Ayman Moawad Mahmoud

Hi Sushil,

We usually go for a therapeutic dose of 1/40 or 1/50 of the LD50.

Best

Sushil Kumar Middha

Thank you sir, i also did the same. As one reviewer askes me this question. So want to cross check. Could you provide me some references for it?

Ikhtifar Rafi

use the does that shows the highest effectiveness for further studies

Alok Nahata

I think the LD50 value for your plant is too high. Acute toxicity studies should have been done. You should consider administering 2000 mg/kg p.o. and if no mortality is observed, then select a 1/10th, 1/20th and 1/40th dose for your experiments. This will also be in accordance with the OECD guidelines.

Dear Dr. Ashok but there was no mortality found on 2g/BW .