EGCG is a compound which does not follow lipiniski rules, so what to do..
can't I use it as ligand?
EGCG has 2 violations of Lipinski's rule of 5, but you can still use it as a ligand. can you tell What gene/ disease you are targeting?
@saif ur rahman..I am targeting for cancee
Any particular gene?
I am confused about 6-311G ** ++ and 6-311G (d,p) ++ basis.. both are synonymous or not? if not what is the difference? #Jaguar #gaussain #DFT #Ab-intio
08 September 2017 9,206 4 View
could anyone please explain a bit about relationship between gibbs free energy and thermodynamic stability of a ligand?
08 September 2017 7,647 0 View
my laptop has corei7 processor and RAM 6 Gb. I want to know about memory and allocation of processor in link tab. last night I tired for 5 core processor and memory 2Gb it said 2070 code...
08 September 2017 5,759 1 View
as i am student and i don't have funding. so i an little bit bemused where should i submit my manuscript for free publication. i am from Bangladesh. is there any opportunity available in any...
07 August 2017 6,217 15 View
I am eagerly waiting for learning and practicing Molecular dynamics. During practice I can not handle software with it's implementation . please help me about this
06 July 2017 918 6 View
I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...
07 August 2024 2,283 2 View
why don't d-orbitals split themselves because of themselves without the presence of ligands? Electrons are indistinguishable. Why wouldn't it be more correct that protons from a ligand split the...
03 August 2024 3,589 3 View
I'm guessing it's because the ligand experiences too much electron repulsion or proton repulsion from the chromium to insert them close to the 3d-orbitals which are close to the metal nucleus. Is...
03 August 2024 1,370 1 View
I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...
03 August 2024 4,725 2 View
Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...
03 August 2024 2,730 1 View
Hello,, The metal complex ligand appears incomplete in the screen of the discovery studio visualizer
30 July 2024 3,354 1 View
Good day, I am a student trying to work on Autodock for a project regarding Ligand-DNA interaction so i am quite new to molecular docking. i have followed tutorials and did all the steps...
28 July 2024 2,136 4 View
I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...
24 July 2024 8,696 0 View
Hello, I am searching for the binding position of a drug in a ribosome, based on previous work indicating it binds there. The resolution of the ribosome-drug Cryo-EM map is around 2.5 Å. I've been...
19 July 2024 2,155 0 View
I am performing fluorescence experiments using a ligand to detect metal ions. I want to determine the Lowest Detection Limit (LOD) using the formula LOD = 3σ / K. However, I'm uncertain about...
19 July 2024 1,086 1 View