For a good FMD vaccine seroconversion must be >90% and it hasnot been achieved in most of states in India (http://www.pdfmd.ernet.in/index_files/Content/Reports/Annual_Report_2017_18.pdf). For successful control of FMD, herd immunity should be about the level of 60% (at least 60% animals should show the protective titre in seromonitoring (Ferrari et al., 2016. Foot and mouth disease vaccination and post-vaccination monitoring Guidelines (http://www.fao.org/3/a-i5975e.pdf) of OIE, FAO. FAO and OIE, December 2016, FAO ISBN: 978-92-5-109349-8; OIE ISBN: 978-92-95108-25-7). However, in biannual FMD vaccination, half to two-thirds of cattle would have low antibody titres after 5 months of the last round (Knight-Jones et al., 2016; www.nature.com/scientificreports/ Scientific Reports | 6:22121 | DOI: 10.1038/srep22121). Two earlier studies on FMD prevention and control stated requirement of >70 immune members in a population. Gleeson and co-workers (GLEESON, L.J., ROBERTSON, M.D., DOUGHTY, W.J., Serological Response of village cattle and buffaloes in Northern Thailand to a newly introduced trivalent foot-and-mouth disease vaccine, ACIAR Proceedings No. 51 - Diagnosis and Epidemiology of Foot-and-Mouth Disease in Southeast Asia, 1993; 38—44) stated that in order to prevent an epidemic 70% of the population need to be protected, but to absolutely prevent an outbreak on a herd basis 95% protection is required (SOEHADJI, M., HERAWATI, S., The experience of Indonesia in the control and eradication of foot-and-mouth disease. ACIAR Proceedings No. 51 - Diagnosis and Epidemiology of Foot and Mouth Disease in Southeast Asia, 1993; 64-69).

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