Which test is appropriate to compare if the sample size between my groups has significant differences?

I have 4 patient groups

group 1: 79 patients

group 2: 99 patients

group 3: 65 patients

group 4: 69 patients

I think the answer may be obvious but its evading me right now :')

My question is I want to know if there is significant differance between the group sizes, before I go ahead and do comparisons. As I want to make sure first that any further conclusions are not because group 2 is scewing my results.

which test do I use? (Using medcalc)

Ty

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