The last decade has seen fantastic progress in the emergence and development of research tools to study neuroscience and interrogate normal and diseased brain function in vitro and in vivo; tools like iPS cells, optogenetics, CRISPR/cas9 etc. I'm interested to hear your opinions about what tools and technologies you think we still need to discover and invent to uncover more of the mysteries of neuroscience and the big neurobiology questions of the day?