Most of the naturally available biodegradable materials such as agarose, chitin, chitosan, collagen, hyaluronan, gelatin etc. have already been explored. What else can I try? How about pectin?
Dear Saha,
Skin regeneration requires scaffolds of well defined characteristics, in terms of tensile properties, micro-structure and morphology, surface modifications by specific cell adhesive proteins, etc. The choice of the polymer is not enough to let you conclude that it works or not, unless you explore the impact of the aforementioned characteristics which I listed above. The micro-fabrication of your scaffold impact the biological performance, the internal structure of the scaffold counts. How did you produce your scaffolds? thin films; non woven mesh, oriented porous scaffolds, filaments deposition? did you explored the impact of these parameters using ONE promising polymer, as gelatin or collagen for example?
I think that the development of scaffold for skin regeneration goes beyond the simple screening of polymers.
Bests,
Irini Gerges, PhD
I agree with you. Its necessary to use a scaffold. Using the biomaterial that I mentioned before it can be to perform a scaffol that permit the interchange of fluid and nutrients to do the regeneneration tissue.
I send you a papaer that deals about this subjet.
Yes, I'm going to use the biomaterials to develop a regenerative scaffold and test the parameters anyway. Thanks for suggestion! So I wanted some suggestions on some novel naturally biodegradable materials to make a scaffold, since most have them have already been explored and published. Maybe a permutation and combination of the ones that are published, I might have to try.
Dear Saha
There are many biopolymers which have been used in the designing of scaffolds of various properties for different purposes. You have to screen the latest papers which introduced new modification ways to improve the properties of polymers for the usage in the treatment of wounds, and try to create original ideas for the fabrication of scaffolds with improved properties over the currently developed ones.
Additionally, you may use already used polymers to develop new scaffolds for skin, but with certain modifications, new composite designing, certain loaded drugs and improved properties of the scaffolds, you can make the scaffold novel.
Dear Saha,
I think that by blending a biopolymer with a synthetic Ones, you may get more suitable results. Because synthetic polymers could cover some
deficiency of naturals such ac low mechanical properties and high degradation rate .
I see some notable properties from polygelyserol sebacate (PGS) for soft tissue and I think that by blending of PGS with a natural polymers you may get some interesting results.
Dear Saha,
I suggest to use a combination of Chitosan with collagen to fabricate a novel scaffold for skin tissue regeneration, maybe by using the electrospinning technique. From this combination you will get very good biological properties and enough mechanical properties suitable for skin regeneration. Moreover, this kind of scaffold will not take long time to be degraded in vivo.
Best Wishes
Mohammed Fayez Al Rez, Ph.D
My suggestion also chitosan,it is not only a good scaffold material but also has ability of regeneration.
Chitosan - is one possible candidate -- but its mechanical properties may need to be augmented with something more stronger like PLGA, etc.
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