I am currently writing a review article about the epigenetic changes involved in the conversion of Tregs into Th17 T cells. I understand that acetylated FoxP3 transcriptional proteins block the IL-2 gene and RORgammt promoter to render Tregs anergic and prevent the formation of the Th17 T cell phenotype. I also understand that histone deacetylases remove FoxP3 acetylation allowing for that Treg to be converted to a Th17 T cell.
No clue, but I'd be very interested in reading the final version once your review has been finished. ;)
Hi Eric. It's in the process of finding a journal. The submission process is tedious because each journal or journal group (eg. Elsever, Willey,etc.) has it's own special formatting. The paper's done and submitted to several journals. While I wait I have to reformat for additional submissions. What the journal groups want you to do is to commit to publishing only with them. That and open access is madding for scientist like myself.
- Badges
- Science topic