Chemically modified tetracyclines (CMTs) are non antibiotic derivatives of tetracycline having very potent immunomodulatory effects. They inhibit pro-inflammatory cytokine and mediators well implicated in pathogenesis of COVID-19 and its complications (MMPs, IL-6 etc.). They have been tested in experimental models of ARDS and sepsis and have shown promising effects. CMT-3 seems to be most promising member of this group and can be a useful tool in preventing/treating severe COVID-19 infection and its complication. Kindly give your inputs. Some useful links are.
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