My question is about size measurement of G2-PAMAM-NH2 dendrimers. I've had problem with size measurement by MALVERN-ZetaSizer (Nano ZS). The PDI value is always unacceptable. Could you help me on this matter. What is your method for the characterization of PAMAM dendrimers? I'll be waiting for your suggestions. Thank you in advance!
Ulf Nobbmann
Here are a few things you can try:
- Centrifuge and/or filter your sample. Does that change the PDI significantly?
- It may be at a pH close to isoelectric point which would lead to aggregation. Does the zeta potential give any insight into the dendrimer charge under your sample conditions?
- Check literature on DLS and these samples http://scholar.google.com/scholar?q=PAMAM+dendrimer+zetasizer+dls&btnG=&hl=en&as_sdt=0%2C44
Also attached are a few general hints on what may be of interest/use to you. Good luck!
http://www.materials-talks.com/blog/2014/11/17/tips-tricks-for-nanoparticle-characterization/
http://www.materials-talks.com/blog/2014/10/23/polydispersity-what-does-it-mean-for-dls-and-chromatography/
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