Beyza Kocak

4 Questions 2 Answers 0 Followers

Questions related from Beyza Kocak

Can the retention time of a hydrophobic drug be shorter than its conjugated form with a hydrophilic polymer in reversed phase chromatography?

The polymer is Amphiphile and Mw: 13000 drug Mw: 412 C18 column-150 * 4.6mm-5 micrometer MF: ACN-THF-Water (43:36:21)

19 March 2017 6,234 5 View

Does tetrahydrofuran cause ester hydrolysis?

I wonder if THF, on its own, has any transesterificaiton potential. I need to seperate an ester conjugate from its acid form by HPLC. Mobile Phase contains ACN:THF:Water. The problem is that I see...

13 March 2017 7,600 3 View

How to optimize the required/adequate time to remove non-encapsulated drug by dialysis against DI water?

Spesifically, for encapsulation protocol of hydrophobic drugs into PAMAM dendrimers, I need to optimize the required/adequate time to remove the non-encapsulated drug by dialysis against DI water....

10 August 2016 7,921 3 View

What is your method for the size characterization of PAMAM dendrimers?

My question is about size measurement of G2-PAMAM-NH2 dendrimers. I've had problem with size measurement by MALVERN-ZetaSizer (Nano ZS). The PDI value is always unacceptable. Could you help me on...

04 November 2015 4,213 1 View