"Mucopolysaccharides, also known as glycosaminoglycans (GAGs), contribute to the inflammatory state of the Shwartzman phenomenon [233–236]. Upon exposure to systemic stress, increases in sulfomucopolysaccharide incorporation occur throughout the body, and this is designated as the “universal nonspecific mesenchymal reaction” [3]."
Thank you, Prof-Dr Abdel-Raheem. According to Hans Selye, at page 264 of his book "Thrombohemorrhagic Phenomena" (1966), Hauss, et al (1962) and Emmrich et al (1964) theorized that the universal nonspecific mesenchymal reaction was the Sanarelli-Shwartzman phenomenon. According to Selye, "[T]his response was indicative of an "acceleration of mesenchymal metabolism". Thank you for sharing the link to the 1962 article. I'm very interested in this topic. Please let me know, if you'd like to discuss this further, perhaps by email.
Hauss, W.H., Junge-Hülsing, G. and Holländer, H.J. (1962). Changes in metabolism of connective tissue associated with ageing and arterio- or atherosclerosis. Journal of atherosclerosis research, 2, 50-61.
Hauss, W.H., Gerlach, U., Junge-Hülsing, G., Themann, H. and Wirth, W. (1969). STUDIES ON THE “NONSPECIFIC MESENCHYMAL REACTION” AND THE 1TRANSIT ZONE” IN MYOCARDIAL LESIONS AND ATHEROSCLEROSIS. Annals of the New York Academy of Sciences, 156, 207-218.
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