Co-evaporation with tolune or pyrimidine for 3-4 times before chromatography purification may help.

I think you can use lyophilization technique for these type of mixtures.

you can use some good hygroscopic (moisture extracting agents) compound or mixtures by keeping your products in moisture free environment.

you can try the freeze-dried method

You can try co-evaporation with n-BuOH 3 times.

If running column chromatography (either automated flash or glass columns), try "dry loading". Dissolve you sample in a solvent, mix with 3-4x the weight of silica, then rotary evaporate to dryness. Add to your solid load cartridge (automated flash) or add to the top of your glass column before adding the sand on top. Run your column as normal. Any remaining water will stick to the silica, and your compound will elute.

This link shows one way to keep the silica out of your rotary evaporator trap, and has links to solid loading: https://www.teledyneisco.com/en-us/chromatography/blog/keep-silica-out-of-your-bump-trap

The freeze-dried technique could be recommended to some extent.

freeze-dried method the best for you