I'm curious as to what the strangest/most unique discoveries people have had over the years. The discovery doesn't necessarily have to have been published either. It can just be something strange that you noticed.
In my laboratory we use Nd:YAG lasers with a 5 nS pulse at 532 nm to do various photoacoustic experiments via optical fiber (standard 1000 um fiber from Thorlabs) to deliver the laser light. I've noticed that under some peculiar alignment circumstances (if the fiber isn't cleaved perfectly flat) the fiber will guide yellow light that I can see through the glasses that block 532 nm at the end of the fiber when I direct the beam into some normal white paper. I checked the laser to make sure that it isn't outputting anything other than 532 nm (it isn't) and I checked to see what colors were being output after the fiber and it was 532 nm along with 543 nm and others. The strange thing was that the light was not constant, on some pulses it would just be 532 nm, on others it would be a mixture. In addition, I checked to make sure that the paper was not fluorescent at 532 nm (it's not). The only thing that changed the yellow light was realigning the fiber.
I figured it was some sort of RAMAN effect, but to me that was the strangest thing I've seen in the lab.