Matrix metalloproteinase (MMPs) and their tissues inhibitors have been suggested to be involved in caries process.
Some papers to help you further:
Abundance of MMPs and Cysteine Cathepsins in Caries-affected Dentin.
Vidal CM, Tjäderhane L, Scaffa PM, Tersariol IL, Pashley D, Nader HB, Nascimento FD, Carrilho MR.J Dent Res. 2014 Mar;93(3):269-74.
Dentin matrix degradation by host matrix metalloproteinases: inhibition and clinical perspectives toward regeneration. Chaussain C, Boukpessi T, Khaddam M, Tjaderhane L, George A, Menashi S. Front Physiol. 2013 Nov 1;4:308
Cysteine cathepsins in human carious dentin. Nascimento FD, Minciotti CL, Geraldeli S, Carrilho MR, Pashley DH, Tay FR, Nader HB, Salo T, Tjäderhane L, Tersariol IL. J Dent Res. 2011 Apr;90(4):506-11.
Hi,
We revealed a lower levels in total MMPs in dental caries compared to dental without caries, both treated with some MMPs inhibitors!
Could you please provide us an interpretation of these results?
Best!
Hello,
diifficult to answer the question without having had the chance to review the protocol,etc.
Hope you understand and appreciate.
BW
I would also suggest:
Role of Dentin MMPs in Caries Progression and Bond StabilityA. Mazzoni, L. Tjäderhane, V. Checchi, R. Di Lenarda, T. Salo, F.R. Tay, D.H. Pashley, and L. Breschi
J DENT RES February 2015 94: 241-251
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