What is the role of hydrogen bonding on the solubility of drugs in lipids?

18 April 2017 1 3K Report

In simple terms, hydrogen bond formation between the solute (drugs) and water favors solubilisation of the solute. Does hydrogen bond have a role in the solubilisation of drugs in lipids?

Linus Okoro

It increases membrane permeability.

Check-up the link below

http://www.sciencedirect.com/science/article/pii/S0960894X12010591

Badges
Science topic

More Karthik Siram's questions See All

What are the recent research topics in combinatorial design theory related to magic rectangles?

Magic squares/latin squares

01 May 2024 8,098 0 View

How to add Graphene material in sentaurus TCAD ???

where to get the material properties that need to be inserted in the .par file

08 February 2024 7,961 0 View

How does polarity affect welding? Whast is the arc physics (in detail) behind this phenomenon?

I am getting conflicting information from the web. Some say it is one way for arc welding and another way for tig welding and mig welding. I need some clarity as to how arc physics works. There is...

05 February 2024 3,017 2 View

Is there any method available for saponification of Paprika?

Is there any method available to saponify the coloring pigments in Chilli?

09 November 2023 800 0 View

Is there any recommended voltage/current to run a 18% SDS-PAGE gel?

To briefly explain my experiment, I add a chemical probe to the protein lysate, the probe covalently binds to several proteins in the lysate and further the probe is tagged to a fluorophore by...

12 October 2023 5,176 0 View

A typical silicon based transistor's Base-Emitter threshold is 0.7 Volts. What if we dope p type with silicon and n type with Germanium or vice versa?

Diving into to the basic concept of semiconductors, we know the Base-Emitter voltage for a typical silicon based transistor is 0.7 Volts when both p type and n type are doped with silicon. What...

31 July 2023 3,628 1 View

Is there any research papers available on yoga effecting on incretin hormone levels?

how the yoga increasing incretin hormone levels along with mechanisms?

28 May 2023 3,164 3 View

Is there any research papers available on the effect of yoga on epigenetics?

how yoga is affecting the epigenetics and is there any mechanisms available?

19 May 2023 4,114 2 View

How to do optimization using linear programming in Integrated Farming Systems?

Optimization is a statistical technique and done by using linear programming. it is being used in farming systems.

11 April 2023 6,647 5 View

How to find valance band postion in terms of V vs NHE from the given valance band spectra?

I've obtained the following graph from valance band spectroscopy. Can someone help me find the exact Valance band position from the obtained graph

30 March 2023 3,605 0 View

How to calculate CCS for Sodiated adduct ions and Multiply Charged Ions?

I'm currently working on calculating the collision cross section (CCS) for various ions, and I'm facing challenges when dealing with sodiated and multiply charged ions. Most of the resources I’ve...

08 August 2024 8,329 0 View

RNA later for the preservation of RNA in fecal samples at room temperature for one day (37°C)?

I am planning to collect human fecal samples for metatranscriptomic analysis using MGI. These samples are from indigenous people living in a region with high temperatures. I will have access to a...

06 August 2024 1,367 3 View

How to understand this crystallographic phenomenon of low temperature crystals in zeolite?

During low-temperature testing, new diffraction peaks that appear could be indicative of several phenomena. In one of our tests, we observed notable new peaks around 40° and 45° in a specific...

06 August 2024 726 3 View

Is it possible to improve the reforming section of the Haber-Bosch process without using air separation units?

A typical reforming section in a large-scale Haber-Bosch process (Figure 1) comprises two reactors. A mixture of methane (CH4) and steam (H2O) is fed into a primary reformer to produce syngas via...

01 August 2024 7,051 5 View

Methyl jasmonate preparation ?

How do I calculate the stock solution to apply 100 uM MeJA for 1000 ml of plant nutrient medium ?

01 August 2024 723 0 View

Inquiry on Maximum Nucleic Acid Volume for 2.5 mL Liposome Solution?

I am currently working on a project involving liposomes and need to determine the maximum volume of siRNA that can be added to a 2.5 mL liposome solution with a total lipid concentration of 10...

30 July 2024 6,420 1 View

Culture fibroblasts with or without FGF2?

I'm new to primary human fibroblast culture and I'm studying aging using cells from old and young donors. Some research groups have used media supplemented with FGF2, so I cultured cells in the...

29 July 2024 3,030 2 View

How can I use DFT-D3 correction ( Siesta version 5.0.1)?

Dear Siesta Users, I installed Siesta 5.0.1 and I want to use Grimme's D3 correction. According to the 5.0.1 manual, I could use a few parameters to include the D3 correction in the...

27 July 2024 5,748 0 View

EDC carbodiimide and NHS easter 's half life among different pH?

It has been long known that EDC carbodiimide and NHS easter's half life agains hydrolysis are highly related to pH. However, very surprisingly, not yet found a paper giving a table/chart of their...

25 July 2024 8,738 0 View

Mechanochemistry: ball to powder mass or ball to powder volume?

I run mechanochemical reactions that involves the use of a large amount of catalyst (1:1 molar ratio to the reactant). When I try to understand the effect of amount of catalyst on the reaction, I...

23 July 2024 9,938 1 View