Is there any convincing evidence that aluminium increases a person's risk of developing Alzheimer's disease?
In the early 80s there were some works that looked for such a link but no
significant evidence was found. As long as we do not know what is the cause
it will be very difficult to connect it with those many environmental factors around us.
When I joined the profession of geriatrics I had the hope that the "secret " of Alzheimer's Dis will be revealed by the year 2006 that marked 100 y since the original describtion of Dr Alois Alzheimer . However, not only my hopes were not fulfilled but now 8 years later and inspite of intensive research we still do not know much ....
Yes, the publication on this topic confirmed this relationship
@ Ashwani Kumar
It is widely accepted that aluminum (Al) is a recognized neurotoxin, therefore it could cause cognitive deficiency and dementia when it enters the brain and may have various adverse effects on central nervous system (CNS). Please have a look at these useful references.
Article Does Aluminum really enhance Alzheimer Disease? Medical impa...
Article Link between Aluminum and the Pathogenesis of Alzheimer's Di...
Article Aluminum in the Diet and Alzheimer's Disease: From Current E...
Article Aluminum and Alzheimer's Disease: After a Century of Controv...
Article Aluminum and Alzheimer's disease: A new look
Article Aluminium in Alzheimer's disease: Are we still at a crossroad?
Article The Potential role of aluminum in Alzheimer's disease
Article A Risk of Alzheimer's Disease and Aluminum in Drinking Water
Article Aluminium as a risk factor in Alzheimer’s disease, with emph...
Article Aluminum and the risk for Alzheimer's disease
Aluminium is a widely recognized neurotoxin that inhibits more than 200 biologically important functions and causes various adverse effects in plants, animals, and humans.
Aluminium is not essential for life. On the contrary, Aluminium is a well established neurotoxin and is suspected to be linked with various neurodegenerative diseases including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinsonism and dementia.
The exact mechanism of aluminium toxicity is not known. However, accumulating evidence suggests that the metal can potentiate oxidative and inflammatory events, leading to tissue damage. A review of the epidemiological and clinical evidence linking aluminium to Alzheimer's disease (AD) is presented.
Aluminium is a trivalent cation that does not undergo redox changes. It has, nonetheless, been implicated in a variety of neurological disorders that have been associated with an increase in the formation of reactive oxygen species (ROS). The exact mechanism of aluminium toxicity is not known. However, accumulating evidence suggests that the metal can potentiate oxidative and inflammatory events, leading to tissue damage. A review of the epidemiological and clinical evidence linking aluminium to Alzheimer's disease (AD) is presented. The article discusses the role of aluminium in two mechanisms that have been linked to neurodegenerative disorders, including AD. Studies are summarized that describe how aluminium can potentiate iron-induced oxidative events. Involvement of aluminium in inflammatory responses, mediated by interleukins and other inflammatory cytokines, is also discussed. Although a direct relationship between aluminium and AD has not been clearly demonstrated, a detailed mechanistic basis for the hypothesis that aluminium may exacerbate events associated with AD is clearly emerging. The results discussed here have broad implications for the role played by aluminium and other metals in neurodegenerative diseases, and suggest that long-term exposure to supra-physiological amounts these metals should be avoided.
please check the link for further details
Article The Potential role of aluminum in Alzheimer's disease
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