Back to the original question - As I recall, DMT is fairly similar to LSD (only much shorter-acting), hitting the 5-HT2A receptor and possibly some melatonin receptors as well. As Rick Massatti said, there were at least a few studies trying to link DMT with schizophrenia; there were many more such studies, even earlier, using LSD. But I think the consensus was that the experiences produced by these 'hallucinogens' is not a close analog of psychosis. Still, the fact that many of the second-generation antipsychotics exert a secondary influence on the 5-HT2A receptor along with their primary dopaminergic effect could reawaken interest in a possible moderating role played by endogenous DMT-like compounds in schizophrenia...

Several older studies have investigated the relationship between DMT and schizophrenia, but I don’t think any of them came to definitive conclusions about the relationship.

Angrist, B., Gershon, S., Sathananthan, G., Walker, R. W., Lopez-Ramos, B., Mandel, L. R., & VandenHeuvel, W. J. A. (1976). Dimethyltryptamine levels in blood of schizophrenic patients and control subjects. Psychopharmacology, 47(1), 29-32.

Bowers, M. B. (1980). Biochemical processes in schizophrenia: An update. Schizophrenia bulletin, 6(3), 393-403.

Schizophrenics typically possess structural abnormalities (e.g., less grey matter & larger ventricle size), which I suspect is more related to the disease onset than DMT. You may want to review the neurodevelopmental theory of schizophrenia to better understand the etiology.

Walker, E., Kestler, L., Bollini, A., & Hochman, K.M. (2004). Schizophrenia: Etiology and course. Annu Rev Psychol, 55, 401-30.

Macêdo, D. S., Araújo, D. P., Sampaio, L. R. L., Vasconcelos, S. M. M., Sales, P. M. G., Sousa, F. C. F., ... & Carvalho, A. F. (2012). Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: A systematic review. Brazilian Journal of Medical and Biological Research, 45(3), 179-186.

Thank you Rick, good stuff to follow up. One point though.....according to Professor John Read, Auckland University and ISPS founder the brain studies for size and ventricle size is laughable. If you had a life time of not responding to the environment around you because someone deemed you not responsible and enough drugs to keep you in a stupefied state so that you were incapable anyway your brain size would be affected. Like any part of the body, lack of use causes loss of structure over time.

I guess an additional question could be do you think a study showing relationship between DMT and SZ or even a single psychotic break would be a) funded and b) published given the power of the pharmaceutical industry and the vested interest in psychosis being a disease model? Perhaps in the same way that a full picture on a news event requires looking at both the mainstream media and alternative media so a middle road conclusion can be formed we need to do the same for medical concepts.

I’m sure a study could be both funded and published as long as it were to have clinical significance. Of course, you would need the appropriate license b/c DMT is a Class A drug in your country. If you are envisioning something along the lines of Dr. Rick Strassman’s exploratory work, then I doubt the study would pass any IRB nowadays.

I am not a clinical researcher, I ask questions to stimulate more questions... In the area of addictions perhaps internally produced drugs are no different from externally produced drugs.

Thinking about DMT in combination with all the other fight/flight chemicals and the desire some people have to feel 'high' I have noticed patterns of risk taking behaviour, drama, seeking stress and unreasonable responsibility, poor food, relationships and sleep pattern choices plus caffeine and nicotine habits which bring these highs on, at the expense of living in a state of ease. Just like any habit there are withdrawals (depression) and cravings (restlessness). The 'high' brings payoffs such as meaning, purpose, involvement, excitement, aliveness, focus, creativity and freedom from social conformity. The cost is 'going too high', burn out, loss of jobs and relationships, the low (a psychic hangover?) and the shame and stigma which follow.... All of which fuel the desire to be high again in order to escape. This keeps going in cycles and is called a mental health disease. Add in the incentive to stay unwell due to income from sickness benefits, paid friends and support, free time not working and I believe we are looking at a very complex issue...... not too unlike other addictive situations.

Daniel Fisher, psychiatrist and consultant to the White House as well as psych survivor found with his research that 80% of people who experience mental health episodes will go on to full recovery in time. However often the 20% who never do recover are portrayed as the yardstick that measures the predicted outcome of the 80%. He found that recovery was more likely without medication, with strong social support but more importantly with a belief from the practitioners that recovery is possible. Abraham Hoffer had a 90% cure rate for SZ using life style and diet changes plus Vit C and B3. Personally I had a failed root canal tooth pulled and went manic so I took high Vit C doses, Vit D and EMPowerPlus, rested with little stimulus and was grounded enough in 4 days to return to uni class. I understand high Vit C will 'sober' up a stoned person very quickly, we understand 'runners high', we understand fever induced delirium so why is 'mental health' in such a different camp?

This is what Wikipedia has to say about DMT....

'Just as with all psychedelics, there is a chance for an onset of paranoia, or a 'bad trip'. This risk is more prevalent with DMT, as DMT is more intense than normal psychedelics. Close attention should be paid to dose, set and setting. Also one should note that along with the lack of physical side effects, the intensity of the DMT experience may enable those currently "labeled with a mental illness," to explore the dimension/s of self. This exploration may have therapeutic efficacy within the individual existing in a state of society/duality.'

If we produce DMT in our own bodies what stops us from producing too much and having an unplanned ''trip'? Is anyone or has anyone studied this? (not industry funded).

O WOW .. good old DMT ... back in the days of the real hippies when Sascha Shulgin was brewing up all sorts of goodies, the great ethnobotanist Richard Evans Schultes (Andrew Weil's Harvard guru, I knew them both - of course Andy's still alive) was giving lectures on natural DMT in a rather potent snuff that was popular in some South American regions he visited. Here - it was known as the "businessmans high" because the effects peaked and receded quickly ... when you compare it agains the other poplar indole alkaloids psilocybin and LSD, that' s a pretty quick trip. Phosphese displays tend to the earthy (LSD is in lighter pastels) ... these serotonin agonists are the basic staples of the natural psychedelic carnival. At least it doesn't hang around a lot, For all-out peace and beauty, you cannot beat 3,4,5 trimethoxy phenyl ethyl amine,but it's wicked hard to find and no fooling, peyote does make you sick .. so I preferred the synthetic (ski lift to the top of the mountain) the thing is, schizophenia etc is an organic problem .. you can get a schizophrenic to use DMT or any drug in those categores, but that sort of mental illness doesn't work on the same biochemistry. At least I think they're operating in different spaces ...

You misunderstand Laurence, I am suggesting that when a person experiences all the trippy things that psychosis brings maybe they are tripping on their own internal and naturally produced chemicals including DMT. Perhaps with less stigma and more understanding plus hydration, nutrition, oxygenation, rest, anti-histamines, high doses of Vit C, D and minerals will 'bring a person down'. Then the need to go high again by stimulating the stress neurotransmitters through behaviour, drama, sleep deprivation etc can be treated like any unnatural addiction.

Um .,,,unnatural addiction? Andy Weil's second book was all about the completely natural tendency to like to "get high" - from twirling around to get dizzy to cats and catnip, Vikings on mead, Siberians on mushrooms, whether we call it sex, drugs, and rock 'n roll or wine, women, and song the human critter delights in altered states,

There's no way we can get enough DMT out of a human (I can see it "new supplement increases natural DMT" .. like those low T ads) . Any stigma has to do with individuals thinking the natural tendency to stretch the limits is in any way annatrual. You should read Oliver Sacks recent work .,. he was experimenting with substances that would makeHunter Thompson faint. Cannabis shot my college work into the Cum Laude category and I don't have THC generators despite what Candace Pert and Soloman Snyder discovered about natural receptors .. we probably have receptors for Pop Tarts if we look hard enough, What you really might look at is the methodologies we use internally to generate over the top personality-erasing biochemical excess characteristic of both terror and ecstasy, which is why people bond in battle and in bed,- that extraordinary electrochemical illusion of being so connected .. when in fact we just blew our specifics to ballyhoo with adrenalin induced neurotransmitter overloads. Between love makes the word go round and the the lure of excitement .,. wars, extreme sports, unfatuation, domestic assualt .. heck ... all of them are chemically induced states of mild insanity, but we don't need anything but patience and meditation to mediate those, right? Let's give the adrenal cortex a little credit for 90% of our whoop de do's. And a side of exotics ... like DMT .. for color.

Back to the original question - As I recall, DMT is fairly similar to LSD (only much shorter-acting), hitting the 5-HT2A receptor and possibly some melatonin receptors as well. As Rick Massatti said, there were at least a few studies trying to link DMT with schizophrenia; there were many more such studies, even earlier, using LSD. But I think the consensus was that the experiences produced by these 'hallucinogens' is not a close analog of psychosis. Still, the fact that many of the second-generation antipsychotics exert a secondary influence on the 5-HT2A receptor along with their primary dopaminergic effect could reawaken interest in a possible moderating role played by endogenous DMT-like compounds in schizophrenia...

Thank you Stephen for for considering the pathways of DMT, When I said addiction I was referring to it in terms of harmful need driven behaviour that adversely affects the person and their community. Of course we are fully driven by all sorts of addictions and seek to find stimulation in many forms, nothing wrong with this. There is a big difference though between a person who feels out of sorts without a daily run and the person who feels the need to drink endless coffees, smoke packs of cigarettes, eat non foods, start fights with others and stay up all night playing video games because they enjoy being on the edge of sanity. Unfortunately if they then cause a car accident the next day without a diagnosis they are idiots but with a diagnosis they are medically excused. If they were aware of their addiction for self stimulated stress chemicals rather than being given a generic diagnosis such as 'borderline personality disorder' perhaps they would chose extreme sports or a daily run over being an idiot. The DSM-5 wants rape to be a mental health issue, is this ethical or is this excusing another extreme addiction?

Heather ... get thself to Amazon and get a copy of Neurotheology: Virtual Religion in the 21st Century ... there's a whole chapter about how people seem ro need a certain amount of "excitement" ... you get a lot in religious activity f course. It's not adddiction, it's normal human behavior. The slogan of Yve Choiunards mountain gear firm is "lets get scared" ... academics get into impossible deadlines, there are so many ways to get the kicks, the excitement and even stressing out worrying about it counts. Look, we're freeakin' primates, we didn't even get chronology and abstracts until about 40,000 years ago when it seems the prefrontals started overseeing that unstructured memory to give only humans that past/present/future that no other critter can do. Not a hard genetic trick .. but we're still primates and we're - well - skittish. The fact we added planning and reflection as late apps doesn't change the chassis - it's only in the last 10,000 years we've made the place safe for people ... cripes, unless you're into Lysenko, we may be cognizent but we're still skittish. Or we want to be ... and that's the key. We think we;re supposed to be in danger, but ,,, um .,. nothing there, So we create artificial thrills and chills to feed that feeing that we're going to be eaten up if we don't get some action - things are too safe? Count on human ingenuity to pull a fire alarm - drugs, activities .. we just gotta get our kicks. No addiction, but an aspect of the human condition. The pathology is when we lose touch ... eg: it''s better to overload on beauty and swoon at a Monet rather than beat so many repetions of a vidogame into the brain that the boundaries get foggy. And ..why say 5HT? There are three ways to say it, you can be blase and say - serotonin - or scholarly and say five hydroxytriptamine, but if we go into initials next is SA behavior for schizoafffective, ED and Low T. Incidentally, I do drink lots of coffee, but since the major affect is caffeine is to degrade adenosine triphosphatase - thus allowing ATP of build up and create in some the semblence of alertness, for me , I like the taste. It's not the coffee, it's the neurotransmitters.

I get all of what you say Laurence, its not the motivation that is being discussed in my opening question.... its a question asking has any one studied the effect of naturally produced DMT during a psychotic episode? It seems logical to me that short lived neurotransmitters such as DMT would have spikes of production that could very well be the cause of hallucinations if they have the same effect when made into an external substance. I am hopeful a stray scientists looking for a PHD subject might read this 'out of the left field question' and be inspired. I am not a scientist, I am a survivor, of funky neutrotransmitters triggerd by mercury poisoning, who has completed a degree in applied mental health and still found the teaching in no way matched the actual experience. I am researching for my own book called mental sense so am happy to learn from others.

Keep up your investigations ... it took methy chloride to put me in the same place that Jill Bolte Taylor got with a stroke, I came back in seconds but a moment of eternity is a moment of eternity pointing out that - of course - heaven was a stage in normal brain death of eternal onness ... perceived in a sense all the way to brainstem, time without end, and ain't that neat. But why the interest in DMT. I would suggest that you look into the definitions of "hallucination" because it's such a loaded word - with the RAS on total alert because the raphe nucleus is overloaded on LSD mimicking good old yes, five hydroxy triptamine, one may conflate the visual exhaustion that makes a telephone pole seem to waver about and say "OMG - it turned into a snake! Eeek" but that's not a true hallucination. A true halllucination means to be aware of something that is simply NOT there, or not be aware of something that is. I think you're including "bizarre delusions" (it's not voices in the head, it's voices on the raidio but he thinks they're personal messages) . .. and even lesser, the typical schizoaffective "non bizarre delusion"(my boss has frowned at me twice this week, I'll bet he wants to fire me, maybe I'd better quit" - which can hide as a cranky personality at times. So it's not what you're adding ... it's what exactly are you adding it too - and I'm glad you survived that mercury .-- that's the sort of Heavy Metal we want to avoid.

My computer has been down so please excuse the time lag.... I cant know another persons experience of hallucination and I am too chicken to ingest something to experiment. So I can only relate to my short lived experience which was as if all social conditioning or boundaries were removed allowing me to see a pattern of energy in everything. As Jill Bolt-Taylor described but for me it involved animals, plants, a connectedness, almost a dance where I was shown a new set of rules. It was scary at first as synchronicities, information overload and excitement caused me to crash but each time after that I learnt, or was shown, how to be calm in it and enjoy. We humans are meaning making machines so we find someone to blame, some logical explanation, make it mythical or otherwise try and avoid simple newness.

To say a true hallucination is something that is not there is like someone dismissing ultra violet or infra red before we had a machine to view it with. We see and hear such a narrow band of what is yet we live as if we have the sum total of knowledge, history shows us most of what we thought was real was not. Dogma, conditioning, controlled education teaches us arrogance, facts but not how to think. You had seconds of letting go, I had 2 or 3 days of this experience, 6 times over 4 years, each time less frightening as I learnt how to be ok with it. People are so frightened of psychosis its like a parent freaking out at a child's tantrum and causing the child to become terrified and traumatized, both escalating the other. Sharman invited these states for spiritual growth, I would rather visit a Sharman than a shrink if I were to ever be psychotic again, at least they would not give me a drug addiction and label to add to my experiences.

A bit more... perhaps psychosis is a right brain experience as described by Dr Jill Bolt-Taylor. Its trippy and expanded and may be triggered by internal stress induced chemicals. Or perhaps its a shorting out of the left brain circuits not associated with a stroke or tumor, perhaps a wacky heightened awareness survival mechanism to view options in a creative 'out of the box' way. Perhaps our minds read the quantum information held in our, and others, electromagnetic fields thereby opening the door to information and later information overload. Perhaps the genetic component is those who are naturally very right brained, creative, intuitive, less conditioned are then more likely to enter these states.

In 1925 science was introduced to quantum physics and understood everything as energy yet medicine, and religion, held on to the notion of material parts and has strongly blocked questions like mine being asked by everyone, especially those deemed unwell for having such thoughts.... a catch 22 which leaves psychosis judged by those who have never experienced it. Yet our diagnostic devices such as imaging technology use quantum science every day.

Although these are my hypothesis based simply on lived experience and extensive reading they still make more sense to me than a disease model. And everyone is different so for some there may well be disease, although the old day definition of disease required some pathology to confirm this rather than a cluster of symptoms. I hope my sharing is at least entertaining or better, thought provoking.

Hi Heather,

Dimethyltryptamine is an extremely fascinating chemical. There's about 150 acacia species here in Australia that contain it, and dozens of species in which it is relatively easily extracted from the bark. In my work we occasionally encounter people making DMT and smoking it for the hallucinogenic effect, which is very intense but short lived.

It (and it's close cousins 5-MeO-DMT and 5-OH-DMT (bufotenin) ) are found in many plants, some of which have been used as ritual hallucinogens by various cultures around the world.

Bufotenin is also the psychedelic substance found in the secretions of some poisonous toads, and 4-phosphoryloxy-N,N-dimethyltryptamine is psilocybin, the active principle in many "magic mushroom" species.

DMT occurs naturally in humans and other mammals, and this endogenous DMT has indeed been conjectured to play a role in all sorts of unusual psychological or neuro-chemical states, although the general consensus of scientific opinion appears to be that "the jury is still out" as to what role it does play.

Endogenous DMT is present in your brain right now, but while various theories have been advanced that fluctuating levels of DMT are responsible for not only for symptoms of schizophrenia, but also for dreams, near death experiences, ecstatic religious visions etc, there is no strong scientific evidence in favour of these conjectures (or against them. Yet?).

While studies show that some people suffering acute symptoms of schizophrenia have higher levels of DMT in their cerebro-spinal fluid than controls, this difference is not statistically significant;

http://bjp.rcpsych.org/content/132/2/139.short

.

This, and similar studies, make it very unlikely that fluctuations in endogenous DMT can be a "one size fits all" explanation symptoms of psychotic disorders.

Much of the hype around DMT can be attributed to this guy:

http://rickstrassman.com/index.php?option=com_content&view=article&id=61&Itemid=60 but unfortunately there isn't any published scientific research at all to back these claims

DMT and it's cousins may actually be useful substances for treating some psychiatric problems, or as adjuncts to psychological counseling.

https://mycotopia.net/forums/attachments/lifestyles/187583d1284163814-pilot-study-psilocybine-treatment-anxiety-patients-advanced-stage-cancer.pdf

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More detailed info on DMT here;

http://www.lycaeum.org/leda/Chemicals/DMT.11.shtml

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The best chemical model for psychosis is probably methylamphetamine. Acute methamphetamine intoxication can produce symptoms that are indistinguishable from frank psychosis induced by schizophrenia, and chronic methamphetamine use also induces symptoms that are very similar to the negative symptoms of schizophrenia;

http://journals.cambridge.org/action/displayAbstract;jsessionid=4DD8B8F7491CA64A385AF69F1662724D.journals?fromPage=online&aid=190565

.

http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.2006.01496.x/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+11+May+from+10%3A00-12%3A00+BST+%2805%3A00-07%3A00+EDT%29+for+essential+maintenance&userIsAuthenticated=false&deniedAccessCustomisedMessage=

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http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0447.1994.tb01541.x/abstract

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Thus, it is likely that dysregulation of dopamine is heavily involved in producing the symptoms of psychotic disorders.

Excellent discussion here;

http://www.schres-journal.com/article/S0920-9964(05)00072-1/abstract

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Contact me privately if you would like a copy of the full-text.

Regards,

Paul.

A very similar hypothesis is that adrenochrome (the oxidation by-product of adrenaline) plays a causal role in schizophrenia. (Adrenochrome was made famous by Hunter S Thompson in "Fear and Loathing in Las Vegas").

Abram Hoffer and Humphry Osmond claim that adrenochrome is a neurotoxic psychotomimetic substance and may be responsible for schizophrenia.

They speculate that megadoses of vitamin C and niacin could be used to treat symptoms of schizophrenia by reducing adrenochrome levels.

http://www.orthomolecular.org/library/jom/1999/articles/1999-v14n01-p049.shtml

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The only real problem with this hypothesis is that adrenochrome is not actually a halllucinogenic substance...

http://www.erowid.org/experiences/exp.php?ID=51847

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http://www.erowid.org/experiences/exp.php?ID=65371

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Alexander Shulgin (who is basically God to most research organic chemists) described adrenochrome as a "fascinating red herring."

The original paper, in which Hoffer obtained "profound psychomimetic symptoms"

from as little as 0.5 mg S.C. or I.V is in J. Mental Sci. 100, 29, '54

However it appears that the original, positive reports were based on experiments with "a single, mentally unstable patient."

http://www.erowid.org/library/books_online/hallucinogens_hoffer_osmond.pdf

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However later research found negative results or no significant effects with doses of up to 25mg:

Am. J. Psychiat. 111, 603, '55

Am. J. Psychiat. 115, 162, '58

Am. J. Psychiat. 116, 454, '59

Lancet ii, 308, '58

These studies led to the conclusion that, while forms of adrenochrome have haemostatic and other physiological properties, adrenochrome is not hallucinogenic, psychotomimetic, or even psychoactive;

Lancet, I 1287, 1960

Sorry I don't have any links to hand for these old articles. There is a good discussion (er- yes- it's wiki) here;

http://en.wikipedia.org/wiki/Abram_Hoffer#Research

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So, just to point out the obvious, don't build elaborate hypothesis upon a sample where n = 1.

I should also point out that mega-doses of Niacin are extremely dangerous, and that liver failure is a particularly unpleasant way to die.

Paul.

Thank you Paul, I am not actively researching at the moment but am part of the movement to get fluoride out of our food and water. This toxin which is more toxic than lead seems to play a large part in poor health, including mental health. In water supplies it has the capacity of stripping lead from old pipes and it carries heavy metal deeper into tissues as it crosses the blood brain barrier and placenta. Funny how fluoride in various forms are included in many medicines including mental health products....

Re returning a psychotic person to a normal state... It seems the details of body and neuro-chemicals is so unclear that a simple strategy of hydration, nutrition, oxygenation, alkalinity and rest is a good idea. High doses of Vit C, D, E, omega oils etc all contribute to this process plus sensible doses of all the other vitamins. Full mineral access allows the body to chose its own medicine, be it zinc, copper, manganese or boron etc. We don't need mental health drugs to exit psychosis, I know this from personal experience. This week I attended a talk about Open Dialogue in Norway, they neither medicate or give a diagnosis but they do give simple sedatives and people do become sane again. Their figures on loss of productivity, cost of medication, lowered revolving door etc are outstanding,

Hi Heather,

You posited >

There have been quite a few studies conducted that measured cerebrospinal levels of endogenous DMT during acute psychosis, like this one;

http://bjp.rcpsych.org/content/132/2/139.short

.

Some of these studies show elevated levels of DMT in some people experiencing psychosis, (compared to controls) but not in all of them. The differences between the acutely psychotic subjects, and the controls, do not reach statistical significance.

This means that there is a possibility that endogenous DMT contributes to some episodes of psychosis, and a possibility that it doesn't. Either way, elevated levels of DMT are not a necessary or sufficient causal factor in themselves. This means even if DMT can play a role in some cases, it is not "THE cause"- it's not sufficient in itself, and it's not present in all (or even most) cases.

It's a very neat and intuitively pleasing hypothesis, but there is a lot of evidence that although it "feels" right, it just isn't the truth.

Many pharmaceuticals (including many anti-psychotics) are fluoridated, because this increases bio-availability and slows metabolism of the drug. You definitely do not want to ingest too much fluoride, but the balance of evidence is that the levels present in medication are not significant.

You also mention "alkalinity". Taking high doses of Vit C will acidify, not alkalise, your sytsemn. Acidifying your system hastens breakdown and excretion of amphetamine type substances, and of mono-amines, and so might have a beneficial effect during acute psychosis, which appears to have a lot more to do with dopamine, (and to a lesser extent serotonin and nor-adrenalin) levels than with DMT or fluorine.

http://www.schres-journal.com/article/S0920-9964(05)00072-1/abstract

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Studies of cerebrospinal fluid of patients in acute psychosis demonstrate that the endo-cannabinoid anandamide is released by the nervous system in response to psychosis or neural injury. Individual neurons that are overstimulated release anandamide, which crosses the synaptic cleft "backwards" and down regulates dopamine release from the presynaptic terminal.

http://www.ncbi.nlm.nih.gov/pubmed/15354183

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CBD, (the second major psychoactive component in cannabis smoke) behaves the same way in the brain as anandamide.

This is probably why people diagnosed with schizophrenia typically report cannabis use decreases the severity of their symptoms in the short term, but also why regular cannabis smoking worsens the prognosis for people with psychotic disorders in the long run (because anandamide is part of a feedback loop that modulates dopamine release, and chronic cannabis smoking down-regulates anandamide release, and makes the receptors for this neurotransmitter less responsive);

http://www.ncbi.nlm.nih.gov/pubmed/23580381

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I do agree that modifying someone's physical and social environments are strategies that are far more likely to lead to long term improvements in the person's mental health and their quality of life than treating them with highly sedating anti-psychotics which have a range of adverse physical and psychological side-effects.

Long before the first anti-psychotics were marketed, there was a movement called "social psychiatry." The drugs have obscured many important insights about simple, cost effective interventions that can greatly improve the individual's life and make things better for the whole community as well.

http://en.wikipedia.org/wiki/Social_psychiatry

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http://isp.sagepub.com/

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Regards,

Paul.

This question has fallen away from the discussion as if DMT is a no thing... Yet it exists within us naturally and in a concentrated form acts like LSD. Does anyone have any new information on DMT?

Thanks for this post Timo,

The review looks interesting. Are you able to upload the full text PDF? (Just respond to this conversation and click on the paperclip to attach a file). 

Regards,

Paul.