The sIgE/IgE ratio is very important for interpreting sIgE results. sIgE measure is kU/l and total IgE measure is IU/l. Can we assume that 1 kU/l=1000 IU/l? If that is not true what is the true relation?
There is no robust relationship. If you add every sIgE you quantify, the result is never total IgE. The presence of unidentified sensitivities or asymptomatic parasitic infestations can contribute to total IgE. Cross reactivity between panallergens may produce an addiction of sIgE result greater than total IgE. The relation between sIgE/total IgE may be quantified during the progress of allergen immunotherapy to monitor the relative contribution of a given allergen to the global clinical picture, but this information must be considered inside the greater clinical context
Thank you Celso for your answer. The point however is about the measure. sIgE is measured in kU/l and total IgE in IU/l. to compare you need to use corresponding measures.
Serum IgE or sIgE is the total amount of IgE in the serum per unit, like IU/ml. Roughly
IU (international unit) is equal to 2 ng. ImmunoCAP IgE is the amount of IgE against a specific antigen, sayl ollen or egg. They are expressed in KU/ml. If the value is less than 0.35 KU/ml is considered negative against that specific antigen.
There is no absolute relation between the sIgE in IU/ml and the ImmunoCap IgE, since the latter only expresses a portion of total IgE.
Shih-Wen Huang
Total IgE=Specific IgE+Non-specific IgE.Specific IgE is the amount of IgE against a specific antigen. The Unit KU/L=KIU/L=1000 IU/L=IU/ml.
Thank you Derrick! You prove me wright Do you happen by chance to attend EAACI meeting in Barcelona?
I'm very sorry that I don't attend EAACI this year, though I did hope to be there.
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