It appear to be useful at the weekly doses 75, 150, 300 mg subcutaneous in patients that did not responded to antihistaminics and systemic steroids. If raised IgE indication appear obvious but it seem useful even if normal IgE. I have scarce anecdotic experience and can not confirm it. Atttached references.
We have about five patients controled with omalizumab in recalcitrant cases of chronic and long running urticaria. I think that a phase III clinical trial is just to be published in order to support its use in chronic idiophatic urticaria.