What is the proportion of ROS generated in the mitochondria versus from NADPH ox in neutrophils and monocytes?
NADPH is generated with ribose 5-phosphate in the pentose phosphate pathway. NADPH has a multi-functional molecule; to help the synthesis of fatty acids and cholesterol, to synthesize reduced glutathione (GSH), to maintain the activity of CYP450, to help synthesize nitric oxide (NO) etc. In the case of neutrophils and monocytes, NADPH is essential for the synthesis of GSH to reduce the redox stress.
Thankyou...for your detailed reply and excellent diagram....I was interested i neutrophil mitochondrial ROS and the balance between this and NADPH oxidase as a source of ROS...
if they are activated, then ROS emission fro mitochondria would be
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