Reportedly this small population is dynamic and pathogenically converts into Th17 cells. CD25lo population, but not CD25hi, shows plasticity towards Th17 cells.
Th17 cells also have regulatory function too ? In the future I had to sort Tregs so they schoud converts into Th17 cells. Is it right that I had to sort T-cells CD4+ CD 25+ low not high
CD25hi which are known as Tregs can even be trans-differentiated into TH17 cells by myeloid derived suppressor cells (MDSCs). Even MDSCs can educate the CD4 + cells to differentiate either into Tregs or Th17 depending upon their phenotype and cytokines secreted.