I would like to do docking to see antimicrobial substance inhibitory activity on the proteins/molecules involved in the pathway for the production of Staphylococcus aureus bio film.
My humble recommendation is to check the 2nd excellent review by Davey and her co-author on genetics, molecular biology, etc. of biofilm forming oral isolates:
Davey and Costerton, 2006. Periodontology 2000, Vol. 42, 2006, 13–26.
Although main focus is streptococci, still could be of help for the genes responsible-related with biofilm formation. Talks about quorum-sensing and quorum-quencing too. Worth to have a look.
cheers
Dear Yan,
1- About the formation of biofilms, please check: Cue et al., Front Cell Infect Microbiol 2012, PMID: 23061050 [available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459252/pdf/fcimb-02-00038.pdf].
2- About the control of death and lysis in Staphylococcal biofilm, please check: Sadykov and Bayles, Curr Opin Microbiol 2012, PMID: 22221897 [available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320683/pdf/nihms346442.pdf].
3- If you are working on a dissertation, please check this thesis written by Sander Croes about Staphylococcus aureus biofilm. [available at: http://arno.unimaas.nl/show.cgi?fid=24927]. You can also find chapters about inhibitory effects of antimicrobials on biofilms in this thesis.
4- Finally, I recommend you to also check this nice review about Staphylococcus epidermidis and its biofilm formation if you are interested. [Otto, Nat Rev Microbiol 2009, PMID: 19609257, available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807625/pdf/nihms156816.pdf].
Regards,
Emran Askari
Hi Yan Yan, I have worked on S. epidermidis, hence I have more refs on their mechanism of biofilm formation (if you want to have read at them, do inform me) but I have a ref on S. aureus & their biofilm formation - hope it helps...
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