I ask for a solvent to be used in reaction of hydrazones with cyclic anhydrides. The method i follow use dry benzene which is not available.
Which alternative solvent will be suitable or will work as the dry benzene?
After banning the use of benzene in teaching laboratories of universities worldwide, teachers of chemistry replaced benzene by toluene "methylbenzene" which is relatively more safe.If the medium of the reaction has to be non-polar, then toluene resembles benzene in this property.
After banning the use of benzene in teaching laboratories of universities worldwide, teachers of chemistry replaced benzene by toluene "methylbenzene" which is relatively more safe.If the medium of the reaction has to be non-polar, then toluene resembles benzene in this property.
Toluene also has the benefit of having an azeotrope with a high amount of water. You can often use an inexpensive grade of solvent and dry it in the reaction flask by distilling a few percent (< 10 %) of the volume at atmospheric pressure. The same applies to xylene (usually a mixture of isomers) but traces of this solvent may be difficult to remove because it is higher boiling. However, since you are presumably getting crystalline products, this may not be a problem.
- Badges
- Science topic