Hello,

I would like to know the optimum number for Aptamer copy (each unique sequence) that we can design in a synthetic DNA library (for SELEX).

I found some companies provide the library with only one copy for each sequence to ensure library high diversity. However, in the case of DEL-small molecules libraries, I found some companies add 100000 copies for each molecule. It is copy number versus diversity I guess. Which strategy is better?

Thank you in advance.

Waleed