I want to tried to give one drug or more as prophylactic treatment to prevent or attenuate covid19 infiltration who much percent in my locality should recive to be evaluated for approval
The number needed to prevent is to be calculated. However, it needs to be interpreted with cost-benefit analysis, the severity of illness, and its infectivity.
Dr. Ijaz sir has already shared articles to get an idea.
With as little as a size of 30, a sample is big enough for the application of the central limit theorem in which case all means can assume normal distributions. With as few as 30 persons you can test for the efficacy of a drug confidently.