Hi，

Glass or PP cryotubes are acceptable.

The answer to this question comes from MedChemExpress Technical Support.

[email protected]

For storing the biosimilar Bevacizumab solution (HY-P9906) to ensure stability and prevent loss of activity, the most suitable container material is

polypropylene (PP) or glass vials, with the decision often depending on the specific application.

MedChemExpress has confirmed that both are acceptable for their product.

Regardless of the container type, standard best practices for handling

monoclonal antibodies must be strictly followed.

Material comparison: Plastic vs. glass

Polypropylene (PP) containers

• Benefits: Studies on bevacizumab stored in PP syringes showed no significant change in physical stability or activity over several months. It is a generally accepted material for storing protein therapeutics.
• Drawbacks: Some general studies have shown protein adsorption to plastic surfaces, especially at low concentrations or without stabilizers. However, this risk appears to be well-managed in the standard formulation.

Glass containers

• Benefits: Glass is a traditional and highly reliable material for protein storage, with extensive historical data on compatibility and stability.
• Drawbacks: Glass vials are prone to breakage and can present issues with surface adsorption if not handled correctly. Certain types of glass can also leach metal ions, although this is rare with Type I borosilicate glass.

The siliconization debate

Whether or not a container should be siliconized is a critical consideration for monoclonal antibodies.

• Siliconized containers: These are coated with a lubricant to reduce protein adsorption and minimize friction for applications like prefilled syringes. However, the silicone oil itself can interact with certain antibodies, potentially causing aggregation, especially under agitation.
• Non-siliconized containers: These remove the risk of silicone-induced aggregation. Studies have shown protein adsorption is lower on hydrophobic polymer surfaces (like COP) compared to hydrophilic glass surfaces. For your short-term aliquot storage or for preventing aggregation from agitation, non-siliconized containers may be preferred.

For the MedChemExpress product HY-P9906, which comes as a liquid formulation, the primary vial is likely glass, but for aliquoting, polypropylene cryotubes or glass vials are recommended.

Key recommendations for storage

Roger Normand Vendette Thank you!