My opinion is that even though a neuronal injury is not visible, ischemic damage or loss of metabolism can be observed, which can provide support, although the result is NOT conclusive. In such a case, PET-FDG.

The most sensitive test to diagnose brain neurotoxicity is Magnetic Resonance Imaging (MRI) with advanced functional and molecular imaging techniques. These approaches provide detailed insights into structural, functional, and metabolic changes caused by neurotoxicity.

MRI, especially with advanced functional techniques like DWI, MRS, and fMRI, provides high-resolution and non-invasive insights into both structural and functional changes. It is beneficial in early detection when structural damage is not yet visible on CT or standard imaging.