Hi all,
I am interested to know the estimated mitochondrial mutation rate (substitutions/site/my) in rodents (actually shrews) with the idea of calibrating a molecular clock (COXII gene). I have seen from the literature that it is common to see Cytb third codon positions for such purpose. I have also come across some papers on the Control Region, but being non coding is not ideal for comparisons. I have little variation (population study) and I just want an 'average' estimate to start from. I really want to avoid the 1%-2% estimate of Brown (1979) as it is most likely to be too conservative and outdated.
Thanks to all for any help/advice on this one.
Michael
Hi Michael, in our recent squirrel paper (Corrie et al. 2015 in J. Hered.) we tested some different substitution rates from Horn et al. (2011) "Mitochondrial genomes reveal slow rates of molecular evolution and the timing of speciation in beavers (Castor), one of the largest rodent species. PLoS ONE 6:e14622." These were based on mitogenomes excluding the CR.
Hi Michael
please, read the articles and if have any quesion, connect with professor Simon Ho.
Many thanks Julia, I will have a look at it and hopefully come up with something that I can use. Thanks Fatemeh, I will read that one too...
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