I used the K2R mutation during my research. However, what is the mechanism of this mutation? Does it affect ATP binding or the phosphate transfer?
I have not found any references about this mutation. Does anyone have some clues?
Lysine to Arginine, If I got that K2R correctly. Yes, R will affect the ATP binding capacity. In my research molecule, people have found that ERCC2 K48R mutation can affect the ATP binding capacity. Wait, I can give you some reference.
1) R.B. Kalish, D.P. Nguyen, S. Vardhana, M. Gupta, S.C. Perni, S.S. Witkin, A single nucleotide A>G polymorphism at position -670 in the Fas gene promoter: relationship to preterm premature rupture of fetal membranes in multifetal pregnancies, Am J Obstet Gynecol. 192(1) (2005) 208-212.
2) http://peds.oxfordjournals.org/content/15/10/783.full
Hope these helps.
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