Some people know how ubiquitin protease ligase E3 is degraded? Perhaps this range is a bit big. If anyone knows any degradation pathway that belongs to E3 ligase, please tell me, thank you very much. Usually everyone is studying how ubiquitin protease degrades the target protein, but I haven't seen the paper about how ligase E3 is degraded. For example, studies have shown that the drug inhibits the expression of the target protein through the ubiquitin-proteasome pathway, and that the drug can upregulate the E3 ligase expression. What is the mechanism for upregulation of this E3 ligase?
Actually VHL protein behaves as an E3 ligand for HIF-1alfa. By studying this system you will understand how E3 is recycled under normal oxygen levels
or destroyed under hypoxia.
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