Is there any material or information onto what exactly is the mechanism of fluoride on developing enamel and timing at which this exposure should occur for fluorosis to develop.
It is believed that fluoride acts during the amelogenesis when ameloblasts are secreting the amelogenin. By excess ion, proteins are formed structurally abnormal, making it impossible to subsequent mineralization. Thank U.
http://www.ncbi.nlm.nih.gov/pubmed/21701193
For the timing, the critical timing for fluorosis as esthetic concern in anterior tooth mineralization is between the age of 1-6 years of age.
The primary dentition develops in utero and therefore if fluorosis occurs in the primary teeth, it would have to occur during this time. On the other hand, the development of the permanent dentition excluding the third molars occurs anywhere between 1 year and 7 years of age, This is the period of time the permanent dentition is vulnerable to fluorosis.
It has been reported that the period of susceptibility to the complete permanent dentition is in the 11 months to 7 years old.
Ishii and Suckling. The severity of dental fluorosis in children exposed to water with a high fluoride content for various periods of time. J Dent Res 1991;70: 952-956.
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