Dear Renzo,

thank you, I got this text today, interesting to read! I also have

Cozzi et al, 006,

Caroub et al 2014 and

Boscarino et al 2015

In daily routine and with DAAs we see a lot of patients loosing symptoms of depression after  the first 2 to 6 successfull treatment-weeks. I try to proof, whether this is only a clinical impression or evidence.

regards

chaim

Maybe the following list includes some publications you do not know yet. Some of them are freely available at RG or at PubMed.

• Boscarino JA, Lu M, Moorman AC, et al. (2015). Predictors of poor mental and physical health status among patients with chronic hepatitis C infection: the Chronic Hepatitis Cohort Study (CHeCS). Hepatology 61(3):802-11.
• Adinolfi LE, Nevola R, Lus G, et al. (2015). Chronic hepatitis C virus infection and neurological and psychiatric disorders: an overview. World J Gastroenterol. 21(8):2269-80.
• Evon DM, Golin CE, Fried MW, et al. (2013). Chronic hepatitis C and antiviral treatment regimens: where can psychology contribute? J Consult Clin Psychol. 81(2):361-74.
• Udina M, Castellví P, Moreno-España J, et al. (2012). Interferon-induced depression in chronic hepatitis C: a systematic review and meta-analysis. J Clin Psychiatry. 73(8):1128-38.
• McNutt MD, Liu S, Manatunga A, et al. (2012). Neurobehavioral effects of interferon-α in patients with hepatitis-C: symptom dimensions and responsiveness to paroxetine. Neuropsychopharmacology. 37(6):1444-54.
• Pavlović Z, Delić D, Marić NP, et al. (2011). Depressive symptoms in patients with hepatitis C treated with pegylated interferon alpha therapy: a 24-week prospective study. Psychiatr Danub. 23(4):370-7.
• Janke EA, McGraw S, Garcia-Tsao G, et al. (2008). Psychosocial issues in hepatitis C: a qualitative analysis. Psychosomatics. 49(6):494-501.
• Schaefer M, Mauss S. (2008). Hepatitis C treatment in patients with drug addiction: clinical management of interferon-alpha-associated psychiatric side effects. Curr Drug Abuse Rev. 1(2):177-87.
• Nelligan JA, Loftis JM, Matthews AM, et al. (2008). Depression comorbidity and antidepressant use in veterans with chronic hepatitis C: results from a retrospective chart review. J Clin Psychiatry. 69(5):810-6.
• Loftis JM, Huckans M, Ruimy S, et al. (2008). Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1beta and tumor necrosis factor-alpha. Neurosci Lett. 430(3):264-8.
• Yawn BP, Rocca LG, Wollan PC. (2008). 10-year trends in the diagnosis and treatment of hepatitis C and concomitant mental health disorders: 1995 to 2005. Prim Care Companion J Clin Psychiatry. 10(5):349-54.
• Robaeys G, De Bie J, Wichers MC, et al. (2007). Early prediction of major depression in chronic hepatitis C patients during peg-interferon alpha-2b treatment by assessment of vegetative-depressive symptoms after four weeks. World J Gastroenterol. 13(43):5736-40.
• Huckans MS, Loftis JM, Blackwell AD, et al. (2007). Interferon alpha therapy for hepatitis C: treatment completion and response rates among patients with substance use disorders. Subst Abuse Treat Prev Policy. 12;2:4.
• Neri S, Pulvirenti D, Bertino G. (2006). Psychiatric symptoms induced by antiviral therapy in chronic hepatitis C: comparison between interferon-alpha-2a and interferon-alpha-2b. Clin Drug Investig. 26(11):655-62.
• Fireman M, Indest DW, Blackwell A, et al. (2005). Addressing tri-morbidity (hepatitis C, psychiatric disorders, and substance use): the importance of routine mental health screening as a component of a comanagement model of care. Clin Infect Dis. 40(Suppl 5):S286-91.
• De Bie J, Robaeys G, Buntinx F. (2005). Hepatitis C, interferon alpha and psychiatric co-morbidity in intravenous drug users (IVDU) : guidelines for clinical practice. Acta Gastroenterol Belg. 68(1):68-80.
• Raison CL, Borisov AS, Broadwell SD, et al. (2005). Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction. J Clin Psychiatry. 66(1):41-8.
• Yates WR, Gleason O. (1998). Hepatitis C and depression. Depress Anxiety. 7(4):188-93.

Thank you very much!

Chaim