What is the impact of Zetapotential of a material in a drug product? What happens if Zetapotential is high and what happens if Zetapotential is low?
The surface energy of a material will dictate its interactions with the surrounding media. Typically surfaces will be polarized as a function of the pH of the solution in which they lay. In case of drug deliveray or storage, the zetapotentail of the material may lead to specific sorption or desorption. Typically people refer to isoelectric point, the pH value at which the charges on the surface of a material are neutralized by anions/cations in solution. This is the point of least charge and the potentail is "not" in the close viscinity of the material.
Dear Dumee,
Thanks for your comment but I need a clarification
In wikipedia it states the ranges of Zeta potential and its stability which shows higher the Zeta potential high is the stability (check link: http://en.wikipedia.org/wiki/Zeta_potential) but in this link where Zeta potential were measured for nanoparticles (https://cdn.shopify.com/s/files/1/0257/8237/files/nanoComposix_Guidelines_for_Zeta_Potential_Analysis_of_Nanoparticles.pdf) states that "Nanoparticles with Zeta Potential values greater than +25 mV or less than -25 mV typically have high degrees of stability" in introduction section. In such case why do they state -25 mV as stable?
Hope I am clear with my query
Hi Ramkumar,
Answering your second question (in a previous comment), the articles mean the range from -25 to +25mV (in some articles -30 to +30mV) as unstable.
Stability itself means the spontaneous attraction, for example, when we are talking about particles in the suspension. For example, look what I've found in "Electrokinetics of heterogenious interfaces" by Zembala, 2004:
"Surface morphology strongly influences interaction
between microscopic objects determining colloid stability. Both van der Waals and electrostatic forces depend on the structure of the interfacial region. Calculations of interaction energy [30] indicate that solid surface roughness is responsible for decreased stability or an increased deposi- tion rate in colloidal systems. When rough particles approach each other (during coagulation) or an adsorbate surface (during deposition), their motion can change the orientation of the sections of approaching surfaces, thus causing the interaction energy to fluctuate."
This leads to a conclusion, that the stability would mean the exclusion of fluctuation in interaction of particles.
Hope it helps!
Best regards,
Kirill
Thanks Krill
It will be great if someone share their ideas for my second query.
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