Having trouble keeping a drug in solution. What is the highest amount of DMSO you can use to dissolve a drug for intracranial infusions? 20% DMSO wasn't enough to keep it in solution. Any other suggestions? Thank you!!
Dear Sadie,
For external use the maximum concentration is 70%. For internal use, no data is available on the maximum percentage. However, I have checked the products of ALZET and found that they use the following:
Commonly used solvents known to be compatible with ALZET pumps*:
* for solvent compatibility with ALZET catheters, please contact technical support at [email protected]
Cyclodextrins
Dextrose, up to 5%, in water or NaCl
N,N-Dimethyl formamide (DMF), up to 25% in water
DMSO, up to 50% in water or polyethylene glycol
DMSO, up to 50% in ethanol (< or =15%) and water
Ethanol, up to 15% in water
Glycerol
1-Methyl-2-Pyrrolidone, up to 12.5% in water
Phosphate buffer
Polyethylene glycol 300 or 400, neat or in water
Propylene glycol, neat or in water
Ringer’s solution (with or without lactate)
Saline, 0.9% (or other aqueous salt solution)
Serum (rat, mouse, etc.)
Solutol, up to 30% in water
Triacetin, up to 5% in water
Tween 80, up to 2%
Water, distilled
Therefore, you can try one or more of this list.
Good luck,
Rafik
Please refer
http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm
Hello Sadie,
Depending on the drug, you could try sonication in a ultrasound bath for a short amount of time ( 50% DMSO => 0% DMSO, it didn't precipitate anymore.
Good luck,
Ivan
Hello all. I have recently done a study using a 20% DMSO solution directly infused into the brain via cannulas (had to use this high of a concentration to dissolve my drug). Vehicle treated animals had no adverse effects, neither did the treated animals (apart from the drug working!). Thanks for your input!
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