BDNF and NGF plays important roles in the regulation of central nervous system and many articles have been published about them. However, I did not find their half-life in the human blood.
Dear Hamed,
Circulating BDNF has been shown to have a half-life of less than 10 min
Pharm Res. 1997 Aug;14(8):1085-91.
Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity.
Sakane T, Pardridge WM.
Exp Neurol. 1994 Jun;127(2):178-83.
Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats.
Tria MA, Fusco M, Vantini G, Mariot R.
...murine NGF has a distribution half-life of about 5.4 min and an elimination half-life of 2.3 h following intravenous injection. When administered by subcutaneous (sc) injection, the elimination half-life is prolonged to 4.5 h. Administration of NGF by sc continuous infusion, using mini-osmotic pumps, provides stable, dose-related levels of circulating NGF within few days from pump implantation. Upon removal of the pump, NGF levels show a rapid decay (t1/2 about 1.5 h) followed by a slow elimination phase (t1/2 about 150 h). These pharmacokinetic parameters might serve for selection of an appropriate administration route and dose regimen that would optimize schedule-dependent expression of NGF therapeutic activity.
Dear Beatrice
Thank you for your valuable information.
Are these information valid for humans?
Dear Hamed,
I suggest that you contact Dr WM Pardridge on the following address:
The behavioral and biochemical effects of BDNF containing
polymers implanted in the hippocampus of rats....
In these studies, EVAc matrices released BDNF throughout the period of time studied, whereas alginate microspheres released the majority of encapsulated BDNF over 1–2 days. The halflife of BDNF in the brain is unknown, however, the half-life of nerve growth factor (NGF), a neurotrophin of similar size and charge, is reported to be less than one hour (Krewson and Sirianni et al. Page 4 NIH-PA Author ManuscriptNIH-PA Author ManuscriptNIH-PA Author Manuscript
Saltzman, 1996). Since BDNF and NGF both activate the Trk family of receptors, it is likely that the half-life of BDNF is also on the order of hours.
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