necrosis is a tissue dead because of microcirculation disorders.  diabetic patient's vessels may be occulted by bacteria, lipids, or glycosylated hemoglobin or collagen.  The most interesting example of necrosis in diabetics is necrobiosis lipoidica disease.  necrobiosis is a status between dead and live of collagen bundles.  And also lipid accumulation occurs in lesion.   İn my opinion for diabetics' necrotic ulsers genetic studies may be focused on lipid metabolism and bacterial killing mecanisms.

Thank you for your answer. I will consider your opinions.

Thanks for the reference.