Which results on motor fluctuations for add on therapies to L-Dopa and which consistency/variability between multiple trials with the same product in the same population.
A good starting point is the Statistical textbook "Studying a Study and Testing a Test" by RK Riegelman and RP Hirsch, 3rd Edn, Little Brown,1996; particularly the chapters 17 & 18 on Diagnostic performance of tests and Comparing tests. The other chapters on Confidence Intervals and Statistical Power calculations will let you compare the literature data to see if the published results are in agreement or not. I use this to teach my Radiation Oncology residents (MDs specializing in Rad Onc) about t6hese topics.
Another question to address is how motor response can be objectively measured between Levodopa alone and add-on therapies. Current measures seem to be subjective (UPDRS) and we are working on tools that will provide objective, observable measures of dose response. Perhaps there is an opportunity for collaboration.
Fully agree Roy. One of the major limitations in PD is that all measures rely on subjective evaluations. It could be interesting to discuss more about development of objective tools.
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