What is the difference between residual solvent and moisture content?
Moisture content is WATER content; residual solvent is about solvent(s) without water in balance, IMHO
By definition, moisture content is the ratio of the mass of water in a sample to the mass of solids in the sample, expressed as a percentage.
For pharmacopeial purposes, residual solvents in pharmaceuticals are defined as organic volatile chemicals that are used or produced in the manufacture of drug substances or excipients, or in the preparation of drug products. The residual solvents are not completely removed by practical manufacturing techniques. Appropriate selection of the solvent for the synthesis of a drug substance or an excipient may enhance the yield, or determine characteristics such as crystal form, purity, and solubility. Therefore, the solvent may sometimes be a critical element in the synthetic process. However, the content of solvents in such products should be evaluated and justified. Because residual solvents do not provide therapeutic benefit, they should be removed, to the extent possible, to meet ingredient and product specifications, good manufacturing practices, or other quality-based requirements. Drug products should contain no higher levels of residual solvents than can be supported by safety data.
For a rapid loss on drying analyzer, look at the Computrac MAX 4000 series of gravimetric analyzers from Arizona Instrument, Chandler, AZ, 85225 USA
For water specific measurements look into the Vapor Pro water content analyzer from Arizona Instrument. www.azic.com
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